Indications for use drugs: treatment of severe infections caused by Gr (+)  m / s, sensitive to the drug - endocarditis, sepsis, osteomyelitis, meningitis  NDSH infection, lung abscess, infection of the skin and soft tissues;  staphylococcal enterocolitis (for use internally ) pseudomembranous colitis  caused by including Clostridium difficile (for use internally). Dosing here Administration of drugs: during  treatment infants and children should be appointed copulation daily doses of 50  - 200 mg / kg / day dose is entered in two ways (every 12 hours) or more,  copulation necessary; newborns (up to 8 days) drug should be given every 12  hours, even daily doses of 300 mg / kg did not cause complications in infants  and children suffering from serious infections. Dosing and Administration of  drugs: for children recommended daily dosage regimen of 40-80 g / kg / day  (activity of sulbactam administered 20-40 mg / kg / day, cefoperazone  20-40mh/kh/dobu) dose copulation be given every 12.6 hours in evenly distributed  doses, with severe or refractory infections the daily dose can be increased to  160 mg / kg when using the ratio 1:1; dose input, distributing it for 2-4 dose  levels; infants 1 week of life the drug should be given every 12 h MDD - 80 mg /  kg. within 7-10 days. Indications for use drugs: disease caused by Gr (-) or  associations Gy (+) and Gr (-) m / o - respiratory infections, sepsis, bacterial  endocarditis, CNS infections (meningitis), abdomen (peritonitis), urinary tract,  acute infection of the skin and soft tissue, biliary tract, bones and here  Per rectum  infection, postoperative infection, otitis. 
 
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